Abstract Search

ea0050oc4.6 | Adrenal and Steroids | SFEBES2017

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

Juszczak Agata , Gilligan Lorna C. , Hughes Beverly A. , Hassan-Smith Zaki K. , Arlt Wiebke , McCarthy Mark I. , Tomlinson Jeremy W. , Owen Katharine R.

Background and aims: HNF1A-MODY causes monogenic diabetes with a lean, insulin sensitive phenotype. Altered glucocorticoid (GC) metabolism has been implicated in the pathogenesis of type 2 diabetes (T2D) and inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which regenerates active cortisol from inactive cortisone have been trialled as a therapeutic approach. 11β-HSD1 is down-regulated in hepatocytes from Hnf1a knock-out mice but the role...

0 shares

ea0050oc4.6 | Adrenal and Steroids | SFEBES2017

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

Juszczak Agata , Gilligan Lorna C. , Hughes Beverly A. , Hassan-Smith Zaki K. , Arlt Wiebke , McCarthy Mark I. , Tomlinson Jeremy W. , Owen Katharine R.

0 shares

Endocrine Abstracts

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

BiosciAbstracts